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DETAILS

Full Chemical Name:                          JWH-018
Systematic IUPAC Name                   Naphthalen-1-yl-(1-pentylindol-3-yl)methanone
CAS Number                                        209414-07-3
ChemSpider Number                         8558143
Molecular Formula                            C24H23NO
Molecular Mass                                  341.45 g/mol

Description

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jwh-018 for sale is a mildly selective agonist of the peripheral cannabinoid (CB2) receptor, derived from the aminoalkylindole WIN 55,212-2. The Ki values for binding central cannabinoid (CB1) and CB2 receptors are 9.0 and 2.94 nM, respectively, for a CB1:CB2 ratio of 3.06.1 . Before searching on where to buy jwh-018,  Its effects on suppression of spontaneous activity, maximum possible antinociceptive effect in the tail-flick assay, and rectal temperature are comparable to those of WIN 55,212-2 when tested in rats.

It is a research chemical that belongs to the naphthoylindole family. jwh-018 for sale as all the other research chemicals in the JWH group is a synthetic cannabinoid with analgesic effects.Its full chemical name is 4-methoxynaphthalen- 1-yl- (1-pentylindol- 3-yl)methanone with chemical formula as C25H25NO2 and molecular mass 371.47 g/mol.

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At least one case of JWH-018 dependence has been reported by the media. The user found where to buy jwh-018 and consumed it daily for eight months. Withdrawal symptoms were more severe than those experienced as a result of cannabis dependence. JWH-018 for sale has been shown to cause profound changes in CB1 receptor density following administration, causing desensitization to its effects more rapidly than related cannabinoids.

On October 15, 2011, Anderson County coroner Greg Shore attributed the death of a South Carolina college basketball player to “drug toxicity and organ failure” caused by JWH-018. An email dated Nov 4, 2011 concerning the case was finally released by the city of Anderson S.C. on Dec 16, 2011 under the Freedom of Information Act after multiple requests by media to see the information had been denied.

Compared to THC, which is a partial agonist at CB1 receptors, finding where to buy jwh-018 and many synthetic cannabinoids are difficult. THC has been shown to inhibit GABA receptorneurotransmission in the brain via several pathways. JWH-018 for sale may cause intense anxiety, agitation, and, in rare cases (generally with non-regular JWH users), has been assumed to have been the cause of seizures and convulsions by inhibiting GABA neurotransmission more effectively than THC. Cannabinoid receptor full agonists may present serious dangers to the user when used to excess.

Various physical and psychological adverse effects have been reported from JWH-018 use. One study reported psychotic relapses and anxiety symptoms in well-treated patients with mental illness following JWH-018 inhalation. Due to concerns about the potential of JWH-018 and other synthetic cannabinoids to cause psychosis in vulnerable individuals, it has been recommended that people with risk factors for psychotic illnesses (like a past or family history of psychosis) not use these substances.

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